| Celery
Seed |
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| Botanical
Name: |
Apium
graveolens |
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| Overview |
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Celery seed is one of the
lesser-known herbs in Western herbal
medicine. However, it has been used for
thousands of years in other parts of the
world for a variety of reasons. During
ancient times, Ayurvedic physicians (vaidyas)
used celery seed to treat people with
colds, flu, water retention, poor
digestion, various types of arthritis,
and certain ailments of the liver and
spleen.
Today, celery seed is used primarily
as a diuretic to promote the excretion
of urine. The diuretic action combined
with the presence of anti-bacterial
compounds in celery seed also make it
useful in treating urinary tract
infections. Laboratory studies have
found that compounds in celery seed and
its essential oil may also help reduce
muscle spasms, calm the nerves, and
reduce inflammation. In fact, some
experts claim that celery seed
alleviates the pain associated with
certain inflammatory health conditions
such as arthritis and gout.
In addition, a few animal studies
suggest that celery seed extracts may
have activity to help lower blood
pressure and cholesterol as well as
protect the liver from damaging agents
such as acetominophen (also called
paracetamol; an over the counter
medication for pain and headache that
can cause liver damage if taken in large
quantities.)
None of these claims, however, have
not been studied in people to date or
backed by rigorous scientific studies.
So, further research is needed to
determine the safety and effectiveness
of celery seed for the conditions
described.
Preliminary animal studies have also
found that celery seed helps prevent the
formation of cancerous tumors in mice.
In a study that included large numbers
of people with and without colorectal
cancer, researchers found that people
who consumed a diet rich in lutein (from
celery, spinach, broccoli, lettuce,
tomatoes, oranges, carrots, and greens)
were significantly less likely to
develop colorectal cancer. It is not
clear, however, whether celery alone
played an important role in the
prevention of this disease and how the
information about these whole foods
relates to the extracts and isolates of
celery seed.
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| Plant
Description |
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The celery plant is slender and
stands about two to three feet tall. It
has three to five segmented leaves, and
flowers with small white petals. Celery
seeds, which are found in the flowers,
are very small, tan to dark brown, and
have a strong, pleasant smell.
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| What's
It Made Of? |
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Celery seeds contain several
substances including volatile oils,
flavonoids, coumarins, and linoleic
acid.
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| Available
Forms |
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- Fresh or dried seeds
- Tablets
- Capsules filled with celery seed
oil
- Celery seed extract, in which the
active ingredients of celery seed
have been extracted by alcohol or
glycerin
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| How
to Take It |
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Pediatric
There are no known scientific reports
on the pediatric use of celery seed.
Therefore, it is not currently
recommended for medicinal purposes in
children.
Adult
Celery seed oil capsules or tablets:
One to two capsules or tablets three
times a day, as directed by your health
care provider.
Celery seed extract: 1/4 to 1/2 tsp
three times a day, or as directed by
your health care provider. (Always take
with plenty of juice or with water at
mealtime, unless instructed otherwise.)
Whole celery seeds: Prepare a tea by
pouring boiling water over one teaspoon
(1 to 3 g) of freshly crushed seeds. Let
it steep for 10 to 20 minutes before
drinking. Drink three times a day.
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| Precautions |
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The use of herbs is a time-honored
approach to strengthening the body and
treating disease. Herbs, however,
contain active substances that can
trigger side effects and that can
interact with other herbs, supplements,
or medications. For these reasons, herbs
should be taken with care, under the
supervision of a practitioner
knowledgeable in the field of botanical
medicine.
Pregnant women should not use celery
seed because it may uterine bleeding and
cause muscle contractions in the uterus.
People with active kidney
inflammation should also avoid this
herb.
Although uncommon, allergic reactions
(even anaphylaxis) to celery seed may
develop in people who handle or ingest
celery. In fact, some individuals who
are allergic to birch pollen may also be
allergic to celery seed.
Active compounds in celery stems and
seeds can cause the skin to become
highly sensitive to UV rays (called
photodermatitis). For this reason,
people taking celery seed should use
sunscreen or sunblock lotions to protect
their skin from the sun.
Celery seeds should not be taken from
a garden packet. Most seeds sold for
these purposes have been treated with
chemicals and should not be taken
internally.
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| Possible
Interactions |
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There are no known scientific reports
of interactions between celery seed and
conventional medications. However, given
that celery seed is an herb with
diuretic effects, people taking
prescription diuretics (such as
furosemide or hydrochlorothiazide)
should not take this herb without first
consulting a healthcare provider.
Similarly, celery contains properties
that may thin the blood, thus making it
somewhat of a concern to take with blood
thinning medications such as warfarin or
aspirin. If you take warfarin in
particular you should not use celery
seed without first consulting your
healthcare provider.
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| Supporting
Research |
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Atta AH, Alkofahi A. Anti-nociceptive
and anti-inflammatory effects of some
Jordanian medicinal plant extracts. J
Ethnopharmacol. 1998;60:117–124.
Banerjee S, Sharma R, Kale RK, Rao
AR. Influence of certain essential oils
on carcinogen-metabolizing enzymes and
acid-soluble sulfhydryls in mouse liver.
Nutr Cancer. 1994;21:263–269.
Abstract.
Blumenthal M, ed. The Complete
German Commission E Monographs:
Therapeutic Guide to Herbal Medicines.
Boston, Mass: Integrative Medicine
Communications; 1998:35-36; 214-215;
245-249.
Boffa MJ, Gilmour E, Ead RD. Case
report. Celery soup causing severe
phototoxicity during PUVA therapy
[letter]. Br J Dermatol.
1996;135(2):334.
Brinker F. Herb Contraindications
and Drug Interactions. 2nd ed.
Sandy, OR: Eclectic Medical
Publications; 1998:52-53.
Duke JA. Handbook of Phytochemical
Constituents of GRAS Herbs and Other
Economic Plants. Boca Raton, Fla:
CRC Press; 1992.
Foster S, Tyler VE. Tyler's Honest
Herbal. 4th ed. New York: The
Haworth Herbal Press; 1999:101-103.
Heck AM, DeWitt BA, Lukes AL.
Potential interactions between
alternative therapies and warfarin. Am
J Health Syst Pharm.
2000;57(13):1221-1227.
Ko FN, Huang TF, Teng CM.
Vasodilatory action mechanisms of
apigenin isolated from Apium graveolens
in rat thoracic aorta. Biochim
Biophys Acta. November 14;
1991;1115:69–74.
Leung AY, Foster S. Encyclopedia
of Common Natural Ingredients Used in
Food, Drugs and Cosmetics. 2nd ed.
New York, NY: Wiley and Sons; 1996.
Miller L. Herbal medicinals: selected
clinical considerations focusing on
known or potential drug-herb
interactions. Arch Intern Med.
1988;158(20):2200–2211.
Newall CA, Anderson LA, Phillipson
JD. Herbal Medicine: A Guide for
Health-care Professionals. London:
The Pharmaceutical Press; 1996.
Ottariano SG. Medicinal Herbal
Therapy. Portsmouth, NH: Nicolin
Fields Publishing; 1999; 82.
Singh A, Handa SS. Hepatoprotective
activity of Apium graveolens and Hygrophila
auriculata against paracetamol and
thioacetamide intoxication in rats. J
Ethnopharmacol. 1995;49:119–126.
Slattery ML, Benson J, Curtin K, Ma
K-N, Schaeffer D, Potter JD. Carotenoids
and colon cancer. Am J Clin Nutr.
2000;71:575-582.
Teng CM, Lee LG, Ko SN, et al.
Inhibition of platelet aggregation by
apigenin from Apium graveolens. Asia
Pac J Pharmacol. 1985;3:85.
Tsi D, Das NP, Tan BK. Effects of
aqueous celery (Apium graveolens)
extract on lipid parameters of rats fed
a high fat diet. Planta Med.
1995;61:18–21.
Zheng GQ, Kenney PM, Zhang J, Lam LK.
Chemoprevention of benzo[a]pyrene-induced
forestomach cancer in mice by natural
phthalides from celery seed oil. Nutr
Cancer. 1993;19:77–86.
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| Review
Date: April
2002 |
Reviewed
By: Participants
in the review process include: Steven
Dentali, PhD (April 1999), Senior
Director of Botanical Science, Rexall
Sundown, Boca Raton, FL; Jacqueline A.
Hart, MD, Department of Internal
Medicine, Newton-Wellesley Hospital,
Harvard University and Senior Medical
Editor Integrative Medicine, Boston, MA;
Gary Kracoff, RPh (Pediatric Dosing
section February 2001), Johnson Drugs,
Natick, MA; Steven Ottariono, RPh,
Veteran's Administrative Hospital,
Londonderry, NH; R. Lynn Shumake, PD
(April 1999), Director, Alternative
Medicine Apothecary, Blue Mountain
Apothecary & Healing Arts,
University of Maryland Medical Center,
Glenwood, MD; Tom Wolfe, P.AHG (April
1999), Smile Herb Shop, College Park,
MD. All interaction sections have also
been reviewed by a team of experts
including Joseph Lamb, MD (July 2000),
The Integrative Medicine Works,
Alexandria, VA;Enrico Liva, ND, RPh
(August 2000), Vital Nutrients,
Middletown, CT; Brian T Sanderoff, PD,
BS in Pharmacy (March 2000), Clinical
Assistant Professor, University of
Maryland School of Pharmacy; President,
Your Prescription for Health, Owings
Mills, MD; Ira Zunin, MD, MPH, MBA (July
2000), President and Chairman, Hawaii
State Consortium for Integrative
Medicine, Honolulu, HI.
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Copyright © 2004 A.D.A.M., Inc
The
publisher does not accept any
responsibility for the accuracy of the
information or the consequences arising
from the application, use, or misuse of
any of the information contained herein,
including any injury and/or damage to
any person or property as a matter of
product liability, negligence, or
otherwise. No warranty, expressed or
implied, is made in regard to the
contents of this material. No claims or
endorsements are made for any drugs or
compounds currently marketed or in
investigative use. This material is not
intended as a guide to self-medication.
The reader is advised to discuss the
information provided here with a doctor,
pharmacist, nurse, or other authorized
healthcare practitioner and to check
product information (including package
inserts) regarding dosage, precautions,
warnings, interactions, and
contraindications before administering
any drug, herb, or supplement discussed
herein.
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