| Gotu Kola |
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| Botanical Name: |
Centella asiatica |
| Common Names: |
Centella, March Pennywort, Indian
Pennywort, Hydrocotyle, Brahmi (Sanskrit), Luei Gong Gen
(Chinese)(Note: Gotu kola should not be confused with
kola nut.) |
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| Overview |
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Gotu kola has been used as a medicinal herb for thousands of
years in India, China and Indonesia. Its ability to heal wounds,
improve mental clarity, and treat skin conditions such as
leprosy and psoriasis were important reasons for its extensive
use in these countries. It has also been called one of the
"miracle elixirs of life" because legend has it that
an ancient Chinese herbalist lived for more than 200 years as a
result of using the herb.
Historically, gotu kola has also been used to treat syphilis,
hepatitis, stomach ulcers, mental fatigue, epilepsy, diarrhea,
fever, and asthma. Today, American and European herbalists use
gotu kola for disorders that cause connective tissue swelling,
such as scleroderma, psoriatic arthritis (arthritis occurring in
conjunction with psoriasis), anklylosing spondylitis (arthritis
of the spine), and rheumatoid arthritis. Recent studies confirm
some of the traditional uses and also suggest possible new
applications for gotu kola, such as lowering high blood
pressure, treating venous insufficiency (pooling of blood in the
veins, usually in the legs, boosting memory and intelligence,
easing anxiety, and speeding wound healing.
Gotu kola should not be confused with kola nut (Cola
nitida). Kola nut is an active ingredient in Coca Cola and
contains caffeine. Gotu kola has no caffeine, and is not a
stimulant.
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| Plant Description |
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Gotu kola is a perennial plant native to India, Japan, China,
Indonesia, South Africa, Sri Lanka, and the South Pacific. It is
a tasteless, odorless plant that thrives in and around water. It
has small fan-shaped green leaves with white or light
purple-to-pink flowers and it bears small oval fruit. The leaves
and stems of the gotu kola plant are used for medicinal
purposes.
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| Medicinal Uses and
Indications |
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| Treatment |
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Wound Healing and Skin Lesions
Gotu kola contains triterpenoids, compounds that have been
shown to aid in wound healing. For example, animal studies
indicate that triterpenoids strengthen the skin, increase the
concentration of antioxidants in wounds, and restore inflamed
tissues by increasing blood supply. Because of these properties,
gotu kola has been used externally for burns, psoriasis,
prevention of scar formation following surgery, recovery from an
episiotomy following vaginal delivery of a newborn, and
treatment of external fistulas (a tear at or near the anus).
Venous Insufficiency and Varicose Veins
When blood vessels lose their elasticity, blood pools in the
legs and fluid leaks out of the blood vessels, causing the legs
to swell (venous insufficiency). In a study of 94 people with
venous insufficiency, those who took gotu kola reported a
significant improvement in symptoms compared to those who took
placebo. In another study of people with varicose veins,
ultrasound examination revealed improvements in the vascular
tone of those who took gotu cola.
High Blood Pressure
In a study of people with heart disease and high blood
pressure, those who took abana (an Ayurvedic herbal mixture
containing gotu kola) experienced a significant reduction in
diastolic blood pressure (pressure on blood vessels when the
heart is at rest) compared to those who took placebo. Further
studies are needed to determine whether gotu kola alone, some
other herb in the Ayurvedic mixture, or the particular
combination of all the herbs in the remedy is responsible for
the beneficial effect.
Anxiety
Triterpenoids (active compounds in gotu kola)
have been shown to soothe anxiety and boost mental function in
mice. A recent study found that people who took gotu
kola were less likely to be startled by a novel noise (a
potential indicator of anxiety) than those who took placebo.
Although the results of this study are somewhat promising, the
dose used in this study was extremely high, making it difficult
to draw any conclusions about how gotu kola might be used by
people with anxiety.
Scleroderma
One study involving 13 females with scleroderma found that
gotu kola decreased joint pain, skin hardening, and improved
finger movement.
Insomnia
Because of sedative effects demonstrated in animals, gotu
kola has been used to help people with insomnia.
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| Dosage and Administration |
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Gotu kola is available in teas, as dried herbs, tinctures,
capsules, tablets, and ointments. It should be stored in a cool,
dry play and used before the expiration date on the label.
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| Pediatric |
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There is currently no information in the scientific
literature about the use of gotu kola for children. Therefore,
it is not recommended for those under 18 years old.
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| Adult |
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The adult dosage of gotu kola may vary depending on the
condition being treated. An appropriately trained and certified
herbalist, such as a naturopath, can provide the necessary
guidance.
The standard dose of gotu kola varies depending on the form:
- Dried herb—to make tea, add ¼ to ½ tsp dried herb to a
cup of boiling water (150 mL) for 10 minutes, 3 times a day
- Powdered herb (available in capsules)—1,000 to 4,000 mg,
3 times a day
- Tincture (1:2, 30% alcohol)—30 to 60 drops (equivalent
to 1.5 to 3 mL – there are 5 mL in a teaspoon), 3 times a
day
- Standardized extract—60 to 120 mg per day; standardized
extracts should contain 40% asiaticoside, 29% to 30% asiatic
acid, 29% to 30% madecassic acid, and 1% to 2% madecassoside;
doses used in studies mentioned in the treatment section
range from 20 mg (for scleroderma) up to 180 mg (in one
study for venous insufficiency; although, most of the
studies for this latter condition were conducted using 90 mg
to 120 mg per day).
The recommended dosage for people with insomnia is ½ tsp of
dried herb in a cup of water taken for no more than 4 to 6
weeks.
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| Precautions |
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The use of gotu kola for more than 6 weeks is not
recommended. People taking the herb for an extended period of
time (up to 6 weeks) should take a 2-week break before taking
the herb again.
Asiaticoside, a major component of gotu kola, has also been
associated with tumor growth in mice. Though more studies are
needed, it is wise for anyone with a history of precancerous or
cancerous skin lesions—such as squamous cell, basal cell skin
cancer, or melanoma—to refrain from taking this herb.
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| Side Effects |
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Side effects are rare but may include skin allergy and
burning sensations (with external use), headache, stomach upset,
nausea, dizziness, and extreme drowsiness. These side effects
tend to occur with high doses of gotu kola.
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| Pregnancy and
Breastfeeding |
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Pregnant women should not take gotu kola because it may cause
spontaneous abortion. There is little or no information
regarding the safety of this herb during breastfeeding, so
nursing mothers should refrain from taking this herb.
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| Pediatric Use |
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Gotu kola is not recommended for children.
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| Geriatric Use |
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People older than 65 years should take gotu kola at a lower
than standard dose. The strength of the dosage can be increased
slowly over time to reduce symptoms. This is best accomplished
under the guidance of an appropriately trained and certified
herbalist such as a naturopathic doctor.
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| Interactions
and Depletions |
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There have been no reports documenting negative interactions
between gotu kola and medications to date. Since high doses of
gotu kola can cause sedation, individuals should refrain from
taking this herb with medications that promote sleep or reduce
anxiety.
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| Supporting Research |
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Antani JA, Kulkarni RD, Antani NJ. Effect of abana on
ventricular function in ischemic heart disease. Jpn Heart J.
Nov 1990: 829-835.
Anonymous. Centella asiatica (Gotu kola). Botanical
Monograph. American Journal of Natural Medicine. 1996;3(6):22-26.
Belcaro GV, Rulo A, Grimaldi R. Capillary filtration and
ankle edema in patients with venous hypertension treated with
TTFCA. Angiology. 1990;41(1):12-18.
Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind,
placebo-controlled study on the effects of Gotu Kola (Centella
asiatica) on acoustic startle response in healthy subjects. J
Clin Psychopharmacol. 2000;20(6):680-684.
Brinker F. Herb Contraindications and Drug Interactions.
2nd ed. Sandy, OR: Eclectic Medical Publication;
1998.
Brinkhaus B, Linder M, Schuppan D, Hahn EG. Chemical,
pharmacological and clinical profile of the East Asian medical
plant Centella asiatica. Phytomed.
2000;7(5):427-448.
Cauffield JS, Forbes HJM. Dietary supplements used in the
treatment of depression, anxiety, and sleep disorders.
Lippincotts Prim Care Pract. 1999:3(3):290-304.
DerMarderosian A, ed. Gotu Kola. In: Facts and Comparisons
The Review of Natural Products. St. Louis, MO: Wolters
Kluwer Co.: 1999:1-3.
Fetrow C, Avila J. Professional's Handbook of
Complementary & Alternative Medicines. Springhouse, PA:
Springhouse Corp.; 1999.
Gruenwald J, Brendler T, Jaenicke C, Fleming T, Deutsch M,
Hamid M, eds. et al. PDR for Herbal Medicines. 1st
ed. Montvale, NJ: Medical Economics Company, Inc..;
1998:729-731.
Kuhn M, Winston D. Herbal Therapy and Supplements: A
Scientific and Traditional Approach. Philadelphia, Pa:
Lippincott; 2001.
McCaleb R. Anti-Cancer Effects of Gotu Kola. HerbalGram.
1996;36:17.
McGuffin M, Hobbs C, Upton R, eds. American Herbal
Products Association's Botanical Safety Handbook. Boca
Raton, FL: CRC Press; 1997.
Miller LG, Murray W J, eds. Herbal Medicinals: A Clinician
Guide. New York, NY: Pharmaceutical Products Press;
1998:217.
Peirce A. Practical Guide to Natural Medicines. New
York: Stonesong Press Inc.; 1999:317-318.
Pointel JP, Boccalon H, Cloarec M, Ledevehat C, Joubert M.
Titrated extract of centella asiatica (TECA) in the treatment of
venous insufficiency of the lower limbs. Angiology
1987;38(1 Pt 1):46-50.
Russo E. Handbook of Psychotropic Herbs. New York, NY:
Hawthorn Herbal Press; 2001.
Shukla A, Rasik AM, Dhawan BN. Asiaticoside-induced elevation
of antioxidant levels in healing wounds. Phytother Res.
1999;13(1):50-54 [abstract].
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| Review Date: March
2001 |
Reviewed By: Participants
in the review process include: Jacqueline A. Hart, MD,
Department of Internal Medicine, Newton-Wellesley Hospital,
Harvard University and Senior Medical Editor Integrative
Medicine, Boston, MA; Gary Kracoff, RPh (Pediatric Dosing
section February 2001), Johnson Drugs, Natick, MA; Steven
Ottariono, RPh (Pediatric Dosing section February 2001),
Veteran's Administrative Hospital, Londonderry, NH; David
Winston, Herbalist, Herbalist and Alchemist, Inc., Washington,
NJ.
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Copyright © 2004 A.D.A.M., Inc
The publisher does not accept any
responsibility for the accuracy of the information or the
consequences arising from the application, use, or misuse of any
of the information contained herein, including any injury and/or
damage to any person or property as a matter of product
liability, negligence, or otherwise. No warranty, expressed or
implied, is made in regard to the contents of this material. No
claims or endorsements are made for any drugs or compounds
currently marketed or in investigative use. This material is not
intended as a guide to self-medication. The reader is advised to
discuss the information provided here with a doctor, pharmacist,
nurse, or other authorized healthcare practitioner and to check
product information (including package inserts) regarding
dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or
supplement discussed herein.
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